Título del libro: Nanomaterials For Wound Healing
Título del capítulo: 3D-Printed Drug-Loaded Nanomaterials for Wound Healing
ALEJANDRO HUERTA SAQUERO; YAAZIEL MELGAREJO RAMIREZ; ALBERTO CABALLERO RUIZ;
Autores externos:
Idioma:
Año de publicación:
2025
Palabras clave:
Alternative therapy; Chronic wounds; Healing process; Healthcare sectors; Microenvironments; Permanent scars; Two-dimensional materials; Wound healing; Wound healing process; Wound management; Nanocomposites
Resumen:
Despite significant advances in chronic wound care, wound management remains a significant challenge and financial burden for patients and the healthcare sector. Many products exist to treat different types of wounds, focusing on various aspects of the healing process, but most strategies focus on using dressings. Depending on the type of wound, the appropriate dressing should be used. However, most dressings are considered two-dimensional (2D) materials, and conventional wound care strategies to treat deep cuts result in the formation of permanent scars. Great efforts have been made to develop alternative therapies that restore the regenerative properties of native skin by restoring skin barrier function in complex situations. Wound healing is a complex and dynamic biological process that requires a suitable environment to promote the wound healing process. Most research has focused on identifying key bioactive molecules and chemokines that can influence the stages of the wound healing process in 2D models. However, the traumatic wounds three-dimensional (3D) structural microenvironment impacts healing. On the other hand, nanotechnology presents unique and alternative approaches to accelerate the healing of chronic wounds through the interaction of nanomaterials during different stages of the wound healing process. Additive manufacturing has revolutionized and transformed traditional approaches in wound management therapies, as they can produce more complex, functional, and personalized three-dimensional architectures with better epithelial tissue mimicking behavior. The combination of additive manufacturing and the effective administration of treatments at the nanoscale allows the development of 3D models of in vitro study of the traumatic wound. In this chapter, we will address the pathophysiology of chronic wounds and their 3D microenvironment. Additive manufacturing and printing technology and materials used to design drug-loaded, 3D-printed nanometer systems for wound healing, 3D bioprinting to make innovative dressings using bioinks, the challenges associated with 3D manufacturing, the progress of clinical applications, and future perspectives will be discussed. © 2025 selection and editorial matter, Mohammed Gulzar Ahmed, Sumel Ashique, Arshad Farid, Gokhan Zengin individual chapters, the contributors.
Entidades citadas de la UNAM:
ISBN:
9781040332030
Editorial:
CRC Press
