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Título del libro: Environmental Factors And Exposure Time Windows Related To The Etiology Of Acute Lymphoblastic Leukemia In Children
Título del capítulo: HTLV-1 as a model for identifying the causes of human leukemia

Autores UNAM:
LUZ MARIA ROCHA RAMIREZ; ELVA JIMENEZ HERNANDEZ; JUAN MANUEL MEJIA ARANGURE;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Palabras clave:

HBZ; HTLV-1; Immune evasion; Leukemia; TAX; Viral leukemia


Resumen:

Leukemia is a complex disease that is associated with several causes, one of which is viral infection. Human T-lymphotropic virus (HTLV) is the most studied virus and is associated with human leukemia. The epidemiology of HTLV-1 has been under investigation in several countries and is now well known. In this context Latin America has shown a high prevalence. Virus family proteins such as Tax and HBZ modulate several signaling pathways that modulate the biological activities of the cell, including cell growth and proliferation, which affect the physiology and immunology of the cell. In this chapter we analyze the most frequent mechanisms induced by HTLV-1 that affect cell proliferation and the immune response to viral infection. The effects on these processes can lead to cell transformation and avoidance of immune recognition of the virus in affected cells. The epidemiological, molecular, and immunological characteristics of HTLV-1 virus involved in leukemia in humans are reviewed. © Springer International Publishing Switzerland 2016.


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