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Título del libro: Pathobiology Of Human Disease: A Dynamic Encyclopedia Of Disease Mechanisms
Título del capítulo: Recent Advances in Genomics of Body Composition, Adipose Tissue MetaboLism, and Its Relation to the Development of Obesity

Autores UNAM:
JUAN CARLOS LOPEZ ALVARENGA;
Autores externos:

Idioma:

Año de publicación:
2014
Palabras clave:

Body mass index; Candidate genes; Cis-eQTL; Epigenetics; Exposome; Extended family pedigrees; Gene expression; Gene-by-environment interaction; Genetical genomics; Genome-wide association studies; Genome-wide Linkage studies; HeritabiLity; Metabolomics; MicroRNAs; Next-generation DNA sequencing; Obesity; Obesogenic environment; Quantitative trait loci; Single-nucleotide polymorphism; Trans-eQTL; Transcriptome mapping; Whole-exome sequencing; Whole-genome sequencing


Resumen:

Obesity is influenced by a complex interaction between the environment, genetic predisposition, and human behavior. The prevalence of obesity, which is a heritable trait that arises from the interactions of multiple genes and Lifestyle factors, continues to increase worldwide, causing health problems and imposing a substantial economic burden on societies. Obesity is at the forefront of international efforts to identify the genetic variation contributing to complex disease susceptibiLity, and recent years have seen considerable success in identifying common risk variants. Nevertheless, despite the enormous success of genetic studies, there are still important gaps in this knowledge. For example, all loci discovered to date in combination only explain <2% of interindividual variation in body mass index (BMI). Given that the heritabiLity of BMI is estimated at 40-70%, it is reasonable to assume that more susceptibiLity loci remain to be uncovered. Recent advances in identifying genetic risk factors for obesity have contributed to understanding disease pathology, which may faciLitate new therapeutic strategies. © 2014 Elsevier Inc. All rights reserved.


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