®®®® SIIA Público

Título del libro: Principles Of Neuro-Oncology: Brain & Skull Base
Título del capítulo: Gene therapy in gliomas

Autores UNAM:
TALIA WEGMAN OSTROSKY;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Brain tumor; Gene therapy; Gliomas; Immunomodulatory gene therapy; Oncolytic viral therapy; Suicide gene therapy; Tumor suppressor gene therapy


Resumen:

Gene therapy is an experimental technique that uses genes to treat or prevent disease. In gliomas different strategies have use: (1) release of suicide genes to produce cytotoxic compounds in the tumor and provoke tumor cell death, (2) oncolytic virotherapy, (3) release of tumor-suppressor genes, (4) immunomodulatory gene therapy, that stimulates an antitumoral immune response, and (5) the use of synthetic vector particles/nanoparticles to deliver genetic material thereby silencing genes essential to tumorigenesis. Several clinical trails have use gene therapy alone or with other therapies in gliomas, but at the time there is not any gene therapy approve for treatment or prevention in gliomas. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2021. All rights reserved.


Entidades citadas de la UNAM: