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Título del libro: Cellular Endocrinology In Health And Disease, Second Edition
Título del capítulo: Endocrine Regulation of Brown and Beige Adipose Tissue

Autores UNAM:
ARIANA ELIZABETH VARGAS CASTILLO; ARMANDO ROBERTO TOVAR PALACIO;
Autores externos:

Idioma:

Año de publicación:
2021
Palabras clave:

Beige adipose tissue; Brown adipose tissue; Obesity; Thermogenesis; UCP-1


Resumen:

In recent years, thermogenesis has gained interest as it can have a significant impact on energy expenditure, and therefore on the control of obesity. It is now known that adipose tissue is of great importance in the generation of thermogenesis because there are two types of adipose tissue, brown and beige adipose tissue, which have thermogenic activity. Although the origin of these two types of adipose tissue is different, both express the uncoupling protein known as UCP1, which uncouples oxidative phosphorylation, generating heat. Several studies have shown that overexpression of this protein in experimental animals makes them resistant to obesity despite consumption of a high-fat diet. This has given it an important relevance in the search of strategies against obesity. Therefore, this chapter shows the importance and origin of brown and beige adipose tissue, as well as its endocrine metabolic regulation. It also shows the physiological, pharmacological, and nutritional inducers, particularly of beige adipose tissue, as well as the future for its application to strategies to treat obesity. © 2021 Elsevier Inc. All rights reserved.


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