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Título del libro: Cellular Endocrinology In Health And Disease, Second Edition
Título del capítulo: Multi-functionality of Pituitary Cells: Biological and Clinical Implications

Autores UNAM:
TATIANA FIORDELISIO COLL; JOSE NICOLAS JIMENEZ PEREZ; MOISES MERCADO ATRI;
Autores externos:

Idioma:

Año de publicación:
2021
Palabras clave:

Adenomas; Multi-functional cells; Multi-hormonality; Multi-responsiveness; Pituitary


Resumen:

The neuroendocrine system allows the organism to respond and adapt and maintain the homeostasis. Although the different hypothalamic-pituitary axes were originally conceived as hierarchical and rigid systems, we now know that such systems are, in fact, rather versatile. It is now clear that the generation of hormonal pulses of the neuroendocrine system depends on complex processes that cannot be explained by a single mechanistic model. Although pituitary cytodifferentiation is a well-established and accepted hierarchical process, certain cells may express receptors for more than one hypothalamic factor and thus respond to non-canonical secretagogues and secrete more than one hormone. The proportion and activity of such multiresponsive and multihormonal cells may vary with age, gender, and physiological/pathological condition. In fact, these cells are likely to be implicated in apparently paradoxical hormonal secretion and in the trans-differentiation of phenotypes which underscores the necessary plasticity to adapt to different physiological conditions in order to maintain homeostasis. In pathological process as pituitary adenomas which are benign epithelial neoplasms that despite being monoclonal for the most part contain large amounts of multi-responsive/multihormonal cells. The precise role of these versatile cells in the oncogenic process that drives the formation of these benign tumors is not well understood. © 2021 Elsevier Inc. All rights reserved.


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