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Título del libro: Mitogen-Activated Protein Kinases (mapks): Activation, Functions And Regulation
Título del capítulo: P38 and JNK as targets of protozoan parasites to manipulate host immune response and survive inside host cells

Autores UNAM:
LAILA GUTIERREZ KOBEH; ARTURO ALFREDO WILKINS RODRIGUEZ;
Autores externos:

Idioma:

Año de publicación:
2019
Resumen:

Intracellular parasites such as Leishmania, Trypanosoma or Toxoplasma need to maintain a propitious environment within the host cell for its survival. In order to accomplish this goal, they have to manipulate several host's signaling pathways in order to inhibit or diminish harmful actions. The modulation of host responses by the MAPK pathways plays an important role on various stages of parasite entry, maturation, survival and duplication. MAPK pathway consists of the extracellular signal-related kinase (ERK), c-Jun N-terminal kinase or stress-activated protein kinase (JNK or SAPK) and MAPK14. Six major families of MAPK have been identified in mammalian cells-ERK1/2, ERK3/4, ERK5, ERK 7/8, JNK 1/2//3 and the p38 isoforms a/b/c (ERK6/d). Different stimuli such as Gicoupled receptors (GPCR), growth factors, inflammatory cytokines or a wide range of environmental, oxidative and genotoxic stresses can activate p38 and JNK pathways. The p38 pathway plays an important role in the regulation of apoptosis, cell cycle arrest, growth inhibition, and differentiation JNK has been implicated in a variety of cellular processes including cell proliferation, apoptosis, autophagy, motility, metabolism, and DNA repair. In this review we will summarize the present knowledge about MAPK, with special emphasis on p38 and JNK. The main focus will be directed towards how these signaling pathways are engaged during some infections with intracellular parasites and how they are manipulated by the parasites to allow their survival inside host cells. © 2019 by Nova Science Publishers, Inc. All rights reserved. All rights reserved.


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