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Título del libro: Ic3k 2019 - Proceedings Of The 11th International Joint Conference On Knowledge Discovery, Knowledge Engineering And Knowledge Management
Título del capítulo: Towards the prokaryotic regulation ontology: An ontological model to infer gene regulation physiology from mechanisms in bacteria

Autores UNAM:
PEDRO JULIO COLLADO VIDES;
Autores externos:

Idioma:
Inglés
Año de publicación:
2019
Palabras clave:

Bacteria; Gene expression; Knowledge engineering; Knowledge management; Physiology; Domain ontologies; Formal ontology; Gene regulation mechanism; Mechanistic interpretations; Ontological modeling; Physiological levels; Regulatory interactions; Transcriptional regulation; Ontology


Resumen:

Here we present a formal ontological model that explicitly represents regulatory interactions among the main objects involved in transcriptional regulation in bacteria. These formal relations allow the inference of gene regulation physiology from gene regulation mechanisms. The automatically instantiated classes can be used to assist in the mechanistic interpretation of gene expression experiments done at the physiological level, such as RNA-seq. This is the first step to develop a more comprehensive ontology focused on prokaryotic gene regulation. The ontology is available at https://github.com/prokaryotic-regulation-ontology Copyright © 2019 by SCITEPRESS ? Science and Technology Publications, Lda. All rights reserved


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