Título del libro: Biomat 2013. Proceedings Of The International Symposium On Mathematical And Computational Biology
Título del capítulo: PROBABILITY DISTRIBUTIONS OF GC CONTENT REFLECT THE EVOLUTION OF PRIMATE SPECIES
MARCO ANTONIO JOSE VALENZUELA; JUAN ROMAN BOBADILLA RODRIGUEZ;
Autores externos:
Idioma:
Inglés
Año de publicación:
2014
Palabras clave:
BASE COMPOSITION; HETEROGENEITY; PERIODICITY; CHROMOSOMES; CHIMPANZEE; SEQUENCE; GENES; MAP
Resumen:
A novel statistics for measuring the (G+C)-content of a given chromosome, which represents the local average distance of GC dinucleotides was derived. We found that this statistics is log-linearly inversely related, for a broad range of scales, to the (G+C)-content in humans, chimpanzee, and rhesus macaque. We also determined the distribution of window sizes for which a given count of GC duplets is found along an entire chromosome. These distributions permit the visualization of how the GC duplet is distributed along a given chromosome and they capture simultaneously GC-poor, GC-intermediate, and GC-rich regions. Interestingly, these distributions followed a quasi-log normal distribution for all chromosomes in the three species and they were fitted to the Black-Scholes stochastic equation. Most deviations from the fittings occurred mainly at the tails that represent GC-poor and GC-rich regions. Some moments of these distributions were clearly different among some primate chromosomes, particularly the mean of several rhesus chromosomes. However, as a whole, the mean, variance, skewness, and kurtosis turned out not to be statistically different among the three primate species. The ratio of (G+C) over the size of each chromosome is practically constant for each chromosome in all the three primate species. This constant ratio imposes limits to the mean and variance of these distributions.
Entidades citadas de la UNAM:
ISBN:
9789814602211
Editorial:
Rubem P Mondaini
Tipo de producto:
Proceedings Paper
