®®®® SIIA Público

Título del libro: Liver Pathophysiology: Therapies And Antioxidants
Título del capítulo: Is Human Cirrhosis a Reversible Disease?

Autores UNAM:
DAVID KERSHENOBICH STALNIKOWITZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2017
Palabras clave:

Antifibrotic therapies; Liver cirrhosis; Liver fibrosis; Liver regeneration; Regression of cirrhosis; Regression of fibrosis; Stellate cells


Resumen:

Liver fibrosis and cirrhosis are associated with increased morbidity and mortality with important health and social consequences. Knowledge of the cells involved in the production of collagen such as hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin and the molecular mechanisms taking place during the development of liver fibrosis have advanced the understanding of the fibrogenic process. Accumulating evidence suggests that liver fibrosis may be reversible and that in some cases recovery of liver cirrhosis may be possible. This has been documented in patients with copper or iron overload, alcohol, chronic hepatitis B and C, autoimmune disease, (non alcoholic steatohepatitis) NASH, or cholestasis. These observations are encouraging and suggest that the liver has a capacity to remodel scar tissue. The most effective antifibrotic treatment is the control of the underlying etiology. Currently a great number of experimental antifibrotic drugs are in clinical trials. © 2017 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: