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Título del libro: Influenza Vaccine And Autoimmune Diseases

Autores UNAM:
LUIS JAVIER JARA QUEZADA; GABRIELA MEDINA GARCIA; MARIA DEL PILAR CRUZ DOMINGUEZ; OLGA LIDIA VERA LASTRA; MIGUEL ANGEL SAAVEDRA SALINAS;

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Autores externos:

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Idioma:
Inglés

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Año de publicación:
2014

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Palabras clave:

ASIA; Autoimmune diseases; Autoimmunity; Influenza H1N1; Vaccines

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Resumen:

In April 2009, H1N1 influenza A virus pandemia began in Mexico. By October 2009, 191 countries had reported more than 375 000 confirmed cases of H1N1/09, with more than 4500 deaths. The majority of cases were mild and self-limiting, but a subset was characterized by serious illness, often requiring hospitalization and mechanical ventilatory support. After this emergency, investigations revealed that the severe disease was a consequence of reactive hemophagocytosis, thrombotic phenomena, lymphoid atrophy, diffuse alveolar damage, and multiorgan dysfunction. This pathological change was associated with a delayed viral clearance and high plasma levels of proinflammatory cytokines and chemokines. The most affected patients were aged between 10 and 39 years. Mortality rates showed high risk in those aged 70 years and older, those with delayed admission, and those showing the presence of chronic diseases. Risk of infection was lower in those who had been vaccinated for seasonal influenza with 2008-9 trivalent inactivated vaccine. In relation to chronic diseases, underlying medical conditions such as diabetes and immune suppression increased the risk of death in patients hospitalized with A/H1N1 infection. The best preventive measure that we currently have is a vaccine. However, the medical community should be alert and report any side effects. Although autoimmune diseases and ASIA have been described in patients receiving influenza A (H1N1) vaccine, the benefits of immunization outweigh the risks. The purpose of this chapter is to analyze the relationship between influenza, vaccination, autoimmunity, and autoimmune diseases, with special emphasis on the A/H1N1 influenza pandemic that occurred in Mexico. © 2015 Wiley-Blackwell.

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Entidades citadas de la UNAM:

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Fuente:


ISBN:
9781118663721
Editorial:
Wiley Blackwell Nombre de la publicación:
Influenza Vaccine and Autoimmune Diseases
Página inicial:
175
Página final:
184

Tipo de producto:
Capítulo de un Libro

DOI:
10.1002/9781118663721.ch18