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Título del libro: Engineering Of Nanobiomaterials: Applications Of Nanobiomaterials
Título del capítulo: Inorganic Nanoflotillas as Engineered Particles for Drug and Gene Delivery

Autores UNAM:
VELUMANI SUBRAMANIAM;
Autores externos:

Idioma:
Inglés
Año de publicación:
2016
Palabras clave:

Carbon nanotubes; Drug delivery; Functionalization; Gene delivery; Gold nanoparticles; Inorganic nanoparticles; Silica nanoparticles; SPIONs


Resumen:

Inorganic nanoflotillas have been exploited immensely as drug/gene and gene delivery systems due to a plethora of physicochemical properties, such as increased surface-to-volume ratio, less toxicity, increased biocompatibility, and efficient biodistribution, affinity towards certain peptides in biological systems for efficient delivery of drug/genes, siRNA, and aptamers. These inorganic nanoplatforms can act as a proficient cargo for delivery of water-insoluble as well as resistant drug/genes, leading to decreased systemic side-effects causing synaphic delivery locally at the desired site. The trafficking of such particles has been studied in detail from receptor-mediated endocytosis to lysosomes and finally exocytosis of the flotillas from the cellular matrix before delivering the drug/genes. This chapter involves different techniques for nanocrystalline synthesis, advanced processing by polymers, efficient tethering of targeting agents such as antibodies, attachment of drug/genes, and delivery of such engineered nanoparticles at the desired site. They possess capabilities of integrating different functionalities, including provision of effective contrast for imaging modalities, synaphic delivery, and thermal therapies. This chapter is an endeavor towards comprehension of complex nanostructures which are emerging as a future avenue for nanomedicine. © 2016 Elsevier Inc. All rights reserved.


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