Título del libro: Scorpion Venoms
Título del capítulo: Recombinant neutralizing antibodies, a new generation of antivenoms
LOURIVAL DOMINGOS POSSANI POSTAY; BALTAZAR BECERRIL LUJAN;
Autores externos:
Idioma:
Inglés
Año de publicación:
2015
Resumen:
The detailed knowledge of the medically important components within the venoms from poisonous animals has prompted the rational generation of improved antivenoms. The new generation of antivenoms, in the case of scorpion envenoming, will be based on the neutralization of the toxins directed against mammalian ion channels, specifically sodium channels. The neutralization of the major toxic molecules declines the lethality of the whole venom. The next generation of antivenoms will depend substantially on the advancements in the field of antibody engineering. The accumulation of detailed information of antibody structure and function proposes that human recombinant antibodies in combination with phage display and directed evolution as a powerful in vitro biotechnological platform alternative to classical antivenoms or monoclonal antibodies for the generation of outstanding therapeutic antibodies. This biotechnological platform has allowed the isolation of safe and efficient recombinant neutralizing antibodies. Many antibody fragments generated using this platform bear exceptional properties that had not been reached using classical approaches. This review describes the great progress that has been achieved on the improvement of antivenoms against scorpion envenoming which have been generated using the already mentioned platform as compared with classical and/or hybridoma approaches. © Springer Science+Business Media Dordrecht 2015.
Entidades citadas de la UNAM:
ISBN:
9789400764040
Editorial:
Springer Netherlands Nombre de la publicación:
Recombinant neutralizing antibodies, a new generation of antivenoms
Página inicial:
139
Página final:
159
