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Título del libro: The Blood-Brain Barrier: New Research
Título del capítulo: Blood-brain barrier (BBB): Morphology and disease

Autores UNAM:
LAURA COLIN BARENQUE; ARMANDO ZEPEDA RODRIGUEZ; ADRIANA ELIZABETH GONZALEZ VILLALVA; MARCELA ROJAS LEMUS; MARTHA PATRICIA BIZARRO NEVARES; VIANEY RODRIGUEZ LARA; FRANCISCO GERARDO PASOS NAJERA; ABEL SANTAMARIA DEL ANGEL; TERESA IMELDA FORTOUL VANDER GOES;
Autores externos:

Idioma:
Inglés
Año de publicación:
2012
Resumen:

Some restricted areas in the body are protected by special structures identified as blood barriers; some examples are: the thymus, the retina, testes, and the thyroid gland. These structures restrict the contact of these organs with the environment selecting the nutrients and other components from the plasma. The brain is part of these selected organs with blood barrier, which is assembled by series of tight junctions with continuous capillaries. Other components of this barrier are the basal lamina, the pericytes and astrocytes feet. There are two barrier systems in the brain, the one located between general circulation and the brain tissue and the one in the choroid plexus. They are different; continuous capillaries that select nutrients from the general circulation in the first case, and in the second by fenestrated capillaries with less selectivity. Because its location and structure, both barriers could be evaluated by morphological techniques to identify their changes in experimental models or in autopsy samples. Histology, Transmission and Scanning Electron Microscopy (TEM and SEM) are excellent tools to evaluate them. This chapter will display information about the normal structures of these barriers and the changes found after the exposure to inhaled pollutants as well as in some human pathology. © 2012 by Nova Science Publishers, Inc. All rights reserved.


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