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Título del libro: Current Technologies To Increase The Transdermal Delivery Of Drugs
Título del capítulo: Sonophoresis: A Valuable Physical Enhancer to Increase Transdermal drug Delivery

Autores UNAM:
JOSE JUAN ESCOBAR CHAVEZ; DALIA BONILLA MARTINEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2010
Palabras clave:

Phonophoresis; Physical enhancers; Skin; Sonophoresis; Transdermal drug delivery; Ultrasound


Resumen:

Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. Ultrasound has been used extensively for medical diagnostics and to a certain extent in medical therapy (physiotherapy, ultrasonic surgery, and hyperthermia). Nevertheless, it has only recently become popular as a technique to enhance drug release from drug delivery systems. A number of studies suggest the use of ultrasound as an external mean of delivering drugs at increased rates and at desired times. This chapter presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and future trends in the field of cutaneous vaccination and gene delivery. © 2010 Bentham Science Publishers Ltd. All rights reserved.


Entidades citadas de la UNAM: