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Título del libro: Molecular Oncology Principles And Recent Advances
Título del capítulo: Cancer immunology and novel strategies for immunotherapy

Autores UNAM:
ALBERTO MONROY GARCIA; MARIA DE LOURDES MORA GARCIA; JORGE HERNANDEZ MONTES;
Autores externos:

Idioma:
Inglés
Año de publicación:
2012
Palabras clave:

Adoptive T cell immunotherapy; Cancer immunoediting; Cancer immunotherapy; Combinatorial therapy; Dysfunctional dendritic cells; Immune tolerance; Immunological escape; Immunosuppression; Inflamation and cancer; Novel tumor immunotherapy; Suppressive m


Resumen:

It is known that the immune system through innate and adaptive immune responses plays an important role to detect and eliminate primary chemically induced or spontaneous tumors. However, according to clinical data and experimental studies using de novo immune-competent mouse models of cancer development, the immune system can also participate as cancer-promoter. In this regard, deficient anti-tumor cell-mediated immunity, in combination with enhanced pro-tumor humoral and/or innate immunity (inflammation), are significant factors influencing malignant outcome. This review describes current knowledge of the interaction between tumors and the immune system, cellular and molecular events that favor tumor immune tolerance and current approaches to control tumor growth trough immunotherapy as well as novel strategies to block immunosuppressive elements. © 2012 Bentham Science Publishers. All rights reserved.


Entidades citadas de la UNAM: